Which of the following is not a side effect of acetaminophen?

Acetaminophen is widely regarded as a safe and effective analgesic and antipyretic when used at recommended dosages. It is commonly used to relieve mild to moderate pain and reduce fever. One of its key characteristics is that it typically does not cause severe headaches as a direct side effect. Instead, it is often utilized to alleviate headaches.

Severe headaches can arise from various underlying conditions or issues but are not a commonly recognized side effect of acetaminophen itself. The other options relate to potential severe side effects or allergic reactions associated with acetaminophen. For example, liver damage can occur, especially with overdose or chronic excessive use, while angioedema and hives may indicate an allergic reaction to the medication, although these are less common.

Understanding these distinctions is vital for safe medication administration and patient education. Patients should be informed that while acetaminophen has a low side effect profile, it's essential to adhere to the recommended dosages to avoid serious complications.